Biomolecule Surface Patterning May Enhance Membrane Association

[button href="http://pubs.acs.org/doi/pdf/10.1021/nn204736b" color="lime_green" target="_blank" id=""]PDF[/button]
[button href="http://arxiv.org/pdf/1202.2310v1" color="sea_foam" target="_blank" id=""]arXiv[/button]

S. Pogodin, N. K. H. Slater and V. A. Baulin

ACS Nano, 6(2), 1308-1313 (2012)

Under dehydration conditions, amphipathic late embryogenesis abundant proteins fold spontaneously from a random conformation into α-helical structures, and this transition is promoted by the presence of membranes. To gain insight into the thermodynamics of membrane association, we model the resulting α-helical structures as infinite rigid cylinders patterned with hydrophobic and hydrophilic stripes oriented parallel to their axis. Statistical thermodynamic calculations using single chain mean field theory show that the relative thickness of the stripes controls the free energy of interaction of the α-helices with a phospholipid bilayer, as does the bilayer structure and the depth of the equilibrium penetration of the cylinders into the bilayer. The results may suggest the optimal thickness of the stripes to mimic the association of such protein with membranes.

[people_short
name=”Vladimir Baulin”
photo=”https://softmat.net/wp-content/uploads/2012/05/baulin1.jpg”
url=”https://softmat.net/t2t_products/baulin/”
] [people_short
name=”Nigel Slater”
photo=”https://softmat.net/wp-content/uploads/2012/05/nigel.jpeg”
url=”https://softmat.net/t2t_products/slater/”
]
Share This Post
Written by Vladimir Baulin
<p>Expertise is computer simulations and theory of soft matter systems. Research is focused on the topics in the theory of Soft matter, polymer physics.</p>

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

* Copy This Password *

* Type Or Paste Password Here *

3,314 Spam Comments Blocked so far by Spam Free Wordpress