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Siyuan Chen

Multifunctional liposomes to combat multidrug resistance

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Amanda Chen

RNA-loaded liposome vaccines

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Alex Chen

Bioengineering of membrane associating polymers and polymer-protein complexes

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Rongjun Chen

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Rongjun Chen

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Antioxidant modified amphiphilic polymer improves intracellular cryoprotectant delivery and alleviates oxidative stress in HeLa cells

Adv Mater Sci, DOI: 10.15761/AMS.1000131 (2017)
Alexander Chen, Sergio A Mercado, Nigel KH Slater
The design and synthesis of a dual-function, cell permeating polymer with an antioxidative property is described and its use for the intracellular delivery of the cryoprotectant trehalose into HeLa cells is demonstrated. The polymer, PVitE-25, was created by grafting the water insoluble hydrophobic […]

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Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Soft Matter, 13, 7571-7577 (2017)
Monika Kluzek, Arwen I. I. Tyler, Shiqi Wang, Rongjun Chen, Carlos M. Marques, Fabrice Thalmann, John M. Seddon, Marc Schmutz
Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers. They provide an appealing road towards the practical use of lipid cubic phases for pharmaceutical and cosmetic […]

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Understanding the interactions between sebum triglycerides and water: a molecular dynamics simulation study

Phys. Chem. Chem. Phys., (2017)
Anna Sofia Tascini, Massimo Noro, Rongjun Chen, John Seddon and Fernando Bresme
In recent years, the sebum oil has been found to play a key role in the regulation of the hydration of the outermost layer of the skin, the stratum corneum. Understanding how a major component of the sebum oil, the triglyceride […]

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pH-Responsive, Lysine-Based, Hyperbranched Polymers Mimicking Endosomolytic Cell-Penetrating Peptides for Efficient Intracellular Delivery

Chem. Mater., DOI: 10.1021/acs.chemmater.7b00054 (2017).
Shiqi Wang and Rongjun Chen
The insufficient delivery of biomacromolecular therapeutic agents into the cytoplasm of mammalian cells remains a major barrier to their pharmaceutical applications. Cell-penetrating peptides (CPPs) are considered as potential carriers for cytoplasmic delivery of macromolecular drugs. However, due to the positive charge of most CPPs, strong non-specific cell […]

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Rome: SNAL workshop within 3rd World Congress on New Technologies (NewTech’17)

 
7 June 2017 from 12:10 to 17:30. The general topic of the meeting is the interactions of lipid membranes with nano-objects including functional biomimetic polymers, polymeric micelles, carbon nanotubes and polymer therapeutic complexes/conjugates to enable the intelligent design of novel materials with improved bilayer modifying properties.
as a apart of
3rd World Congress on New Technologies (NewTech’17)
Given the large […]

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Membrane-Anchoring, Comb-Like Pseudopeptides for Efficient, pH-Mediated Membrane Destabilization and Intracellular Delivery

ACS Appl. Mater. Interfaces, Article ASAP (2017)
Siyuan Chen, Shiqi Wang, Michal Kopytynski, Marie Bachelet, and Rongjun Chen
Endosomal release has been identified as a rate-limiting step for intracellular delivery of therapeutic agents, in particular macromolecular drugs. Herein, we report a series of synthetic pH-responsive, membrane-anchoring polymers exhibiting dramatic endosomolytic activity for efficient intracellular delivery. The comb-like […]

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Amino Acid Based Hydrogels with Dual Responsiveness for Oral Drug Delivery

Macromol. Biosci. (2016)
Shiqi Wang, Xiaoxue Liu, Ignacio J. Villar-Garcia and Rongjun Chen

This study reports a series of novel amino acid based dual-responsive hydrogels. Prepared by a facile one-pot 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) coupling reaction, the solid content, structure, and mechanical behavior of hydrogels could be easily adjusted by changing the concentrations of the polymers and the crosslinkers. With pH-responsive anionic pseudo-peptides […]

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Dresden: Management meeting and Mid-term review

11-12 April 2016. Management meeting and mid-term review

Agenda:
Venue:
Meeting will be held at Leibniz Institute for Polymer Research Dresden
Leibniz-Institut für Polymerforschung Dresden e.V.
Hohe Str. 6, Dresden

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Summer School in Roccalumera

With the sound of waves breaking on the sand, a new generation of scientists was learning, questioning, and interacting with their peers. Such a social experience is always fruitful because it helps people to understand each other and create unique moments which will be remembered.
The summer school in Roccalumera (Sicily, Italy) aimed to bring together […]

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Fundamentals and applications of lipid membrane biophysics

Horsley Park, 22nd-24th September 2015

Researchers from the ITN-SNAL network have met again to discuss the frontiers in the biophysics and biochemistry of lipid membranes. Throughout the two-day meeting (22.09.2015 – 24.09.2015) held in Horsley Park, UK, young researchers had a unique opportunity for active interactions with experts in the field. By showing their latest results […]

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SNAL @ Imperial Festival

Discover why a ‘split personality’ makes fat molecules key to life, and play with a sticky polymer slime you can make at home.

From the 8th to the 10th of May, the Imperial Festival returns for the fourth time, opening its doors so that visitors can see, with their own eyes, some of the research carried […]

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Imperial College London: Fundamentals and Applications of Lipid Membrane Biophysics

Dates: 22nd-24th September 2015
Location: Horsley Park (Ockham Road South, East Horsley, KT24 6DT)

SCOPE
Lipid membranes are the basic building blocks for almost all living organisms. For years numerous reports have been focused on this area to establish a comprehensive understanding of membrane structures. More recently, the development of modern experimental techniques, such as small-angle X-ray scattering, small-angle neutron scattering and […]

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Manchester: 2D Materials and Interfaces

Lectures on Physics of Graphene, Lipids and Proteins
Dates: 9-10 April 2015
Location: School of Physics and Astronomy, University of Manchester, Manchester, UK

The lectures will be delivered by several invited experts as well as PIs in the training network. The courses will teach basic science and discuss recent advances in 2D materials research exploring their unique properties and […]

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Informal ESR meeting of ITN SNAL network 6/7 Novembre 2014

6-7 November 2014 – Roda de Barà, Tarragona, Spain
The second article of the Press Release section will be dedicated to the two days spent in Tarragona and organized by the MSCA Early Stage Researchers (ESRs).

This meeting aimed to point out the role of ESRs within the ITN-SNAL Network, its possibilities and improve the relationships between the […]

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Summary of the Meeting in Cambridge 1 October 2014

1-2 October 2014 – Cambridge, Department of Chemical Engineering at the University of Cambridge.

After months of discussions and proposals conducted by supervisors from each host institution and the program director, Dr. Vladimir Baulin, the management meeting in Cambridge sets the beginning of a great adventure!
In an atmosphere both earnest and casual, many topics have been […]

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Chanfei Su

Modelling of interactions between membranes and spherical and aspherical nano-particles

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Shiqi Wang

Synthesis and characterization of functional biomimetic polymers for intracellular delivery

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Anna Sofia Tascini

Atomistic and coarse-grained simulations, molecular dynamics

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ESR10-C: Bioengineering of membrane associating polymers and polymer-protein complexes

Investigation of membrane associating polymers, therapeutic nanoparticles and cell preservation experiments
Biotechnology and and bioengineering, experimental
Contact
Alex Chen
Objectives

A safe polymer technology, which can be fine-tuned to deliver a wide variety of payloads into cells for various applications.
Novel pH-responsive, biodegradable polymers will be synthesized to mimic the activity of viruses, both in their cell entry and endosomal escape […]

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Dual modes of antitumor action of an amphiphilic peptide A9K

Hai Xu, Cui Xia Chen, Jing Hua, Peng Zhou, Ping Zeng, Chang Hai Cao, Jian Ren Lu
Biomaterials, 34, 2731-2737 (2013)
Following our recent report of attractive antibacterial properties of a designed amphiphilic peptide, A9K, we have investigated its antitumor activities by examining the modes of its action against different mammalian cell types. The peptide strongly inhibited […]

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Molecular mechanisms of antibacterial and antitumor actions of designed surfactant-like peptides

Cuixia Chen, Jing Hu, Shengzhong Zhang, Peng Zhou, Xichen Zhao, Hai Xu, Xiubo Zhao, Mohammed Yaseen, Jian R. Lu

Biomaterials, 33 (2), 592–603 (2012)

Biomimicry of antimicrobial peptides secreted by innate immune systems represents a major strategy in developing novel antibacterial treatments. There are however emerging concerns over the possible compromise of host natural defenses by these […]

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Expertise

All People

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