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Marcus Muller

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Nanomaterial interactions with biomembranes: Bridging the gap between soft matter models and biological context

Biointerphases 13, 028501 (2018); https://doi.org/10.1116/1.5022145
M. Werner, T. Auth, P. A. Beales, J. B. Fleury, F. Höök, H. Kress, R. C. Van Lehn, M. Müller, E. P. Petrov, L. Sarkisov, J.-U. Sommer and V. A. Baulin
Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and […]

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Training course in Strasbourg

As the year 2015 was coming to its end, SNAL ESRs gathered again in Strasbourg to get their last dose of new and contemporary ideas in the field of Lipid Membrane Research. The aim of this training course was to expose ESRs working from the different aspects of same research field, namely synthesis, theory and […]

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Mechanisms of Vesicle Spreading on Surfaces: Coarse-Grained Simulations

Marc Fuhrmans, Marcus Müller

Langmuir, 29 (13), pp 4335–4349 (2013)

Exposition of unilamellar vesicles to attractive surfaces is a frequently used way to create supported lipid bilayers. Although this approach is known to produce continuous supported bilayer coatings, the mechanism of their formation and its dependence on factors like surface interaction and roughness or membrane tension as […]

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Exploring thermodynamic stability of the stalk fusion-intermediate with three-dimensional self-consistent field theory calculations

Kostas Ch. Daoulas, Marcus Müller

Soft Matter, 9, 4097-4102 (2013)

The prospects of compressible Self-Consistent Field (SCF) theory schemes for describing structures in amphiphilic membranes are illustrated by considering the thermodynamic stability of hourglass-shaped, hydrophobic connections (stalks) between apposed bilayers. The membranes are represented by a coarse-grained, solvent-free model. We represent the chain architecture […]

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Transition Path from Two Apposed Membranes to a Stalk Obtained by a Combination of Particle Simulations and String Method

Marcus Müller, Yuliya G. Smirnova, Giovanni Marelli, Marc Fuhrmans, and An-Chang Shi

Phys. Rev. Lett. 108, 228103 (2012)

The formation of an hourglass-shaped passage (stalk) connecting two apposed membranes is an essential initial step in membrane fusion. The most probable transition path from two separate membranes to a stalk, i.e., the minimum free-energy path (MFEP), is […]

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Line-Tension Controlled Mechanism for Influenza Fusion

Herre Jelger Risselada, Giovanni Marelli, Marc Fuhrmans, Yuliya G. Smirnova, Helmut Grubmüller, Siewert Jan Marrink, Marcus Müller

PLoS ONE 7(6): e38302 (2012)

Our molecular simulations reveal that wild-type influenza fusion peptides are able to stabilize a highly fusogenic pre-fusion structure, i.e. a peptide bundle formed by four or more trans-membrane arranged fusion peptides. We rationalize that the […]

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