Research

Formation and Stabilization of Pores in Bilayer Membranes by Peptide-like Amphiphilic Polymers

Soft matter, 2018, DOI: 10.1039/C7SM02404E,
Ankush Checkervarty, Marco Werner, and Jens Uwe Sommer
We study pore formation in models of lipid-bilayer membranes interacting with amphiphilic copolymers mimicking anti-microbial peptides using Monte Carlo simulations and we rationalize our results by a simple brush-model for the fluid membrane. In our study a weak tension on the membrane is required […]

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Formation and Stabilization of Pores in Bilayer Membranes by Peptide-like Amphiphilic Polymers

Soft matter, 2018, DOI: 10.1039/C7SM02404E, Ankush Checkervarty, Marco Werner, and Jens Uwe Sommer. We study pore formation in models of lipid-bilayer membranes interacting with amphiphilic copolymers mimicking anti-microbial peptides using Monte Carlo simulations and we rationalize our results by a simple brush-model for the fluid membrane. In our study a weak tension on the membrane […]

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ESR3-D: Monte Carlo simulations of lipid membranes and their interactions with copolymers

Theoretical physics, theory in soft matter, computer simulations
Contact
Ankush Checkervarty
Objectives
The challenge of this project is to rationalize the inter effective interactions between amphiphilic copolymers and self-organized lipid bilayer membranes using coarse-grained Monte Carlo methods:

Analyze the effect of many copolymers interacting with a fluctuating membrane
Finding copolymer sequences which match particular tasks such as increasing permeation or disruption
Simulating membranes […]

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