Research

Antioxidant modified amphiphilic polymer improves intracellular cryoprotectant delivery and alleviates oxidative stress in HeLa cells

Adv Mater Sci, DOI: 10.15761/AMS.1000131 (2017)
Alexander Chen, Sergio A Mercado, Nigel KH Slater
The design and synthesis of a dual-function, cell permeating polymer with an antioxidative property is described and its use for the intracellular delivery of the cryoprotectant trehalose into HeLa cells is demonstrated. The polymer, PVitE-25, was created by grafting the water insoluble hydrophobic […]

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Fluoresce-Activated Cell Sorting (FACS)

Flow cytometry is a laser-based biophysical technology employed in cell counting, cell sorting, and biomarker detection. Cells or materials are suspended in a stream of fluid and passed through the electronic detection apparatus. The equipment allows simultaneous multiparametric analysis of physical and chemical characteristics up to thousands of particles per second.

Fluorescence-activated cell sorting (FACS) is […]

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Summary of the Meeting in Cambridge 1 October 2014

1-2 October 2014 – Cambridge, Department of Chemical Engineering at the University of Cambridge.

After months of discussions and proposals conducted by supervisors from each host institution and the program director, Dr. Vladimir Baulin, the management meeting in Cambridge sets the beginning of a great adventure!
In an atmosphere both earnest and casual, many topics have been […]

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ESR10-C: Bioengineering of membrane associating polymers and polymer-protein complexes

Investigation of membrane associating polymers, therapeutic nanoparticles and cell preservation experiments
Biotechnology and and bioengineering, experimental
Contact
Alex Chen
Objectives

A safe polymer technology, which can be fine-tuned to deliver a wide variety of payloads into cells for various applications.
Novel pH-responsive, biodegradable polymers will be synthesized to mimic the activity of viruses, both in their cell entry and endosomal escape […]

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