Research

Frankfurt: Course on toxicology and molecular biology techniques

3-5 December 2015
Core training course
The course will cover such topics as methodology, models, and statistical estimation and hypothesis tests.
Introductory course on toxicological evaluation of materials, basic cell and molecular biology techniques
Given the large differences in background between experimental and theoretical/computational ESRs, training courses will aim to highlight these two areas at different levels.
Thursday, 3th of December […]

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Human cell culture models

The REPAIR-lab will use human in vitro systems to study the cellular effects of the nano-objects developed by the other partner laboratories.  The use of complete cells represents the most complex of the in vitro models available in the consortium.
The REPAIR-lab has human cell culture models of different complexity, beginning with permanent cell lines of […]

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ESR11-F: Delivery of molecular payloads through primary human cell membrane

In-vitro experiments on living cells, toxicology studies
Contact
Andre Dias
Objectives
The goal is to compare and validate the synthetic lipid models to biologically relevant cell types and to investigate how different nano-objects interact with representative lipid single and bilayers compared to human cells with and without therapeutic incorporation.
Tasks and methodology

Cellular uptake of fluorescence-labelled nano-complexes will be checked by […]

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ESR12-F: Toxicity of nano-objects on human cells models

In-vitro experiments on living cells, toxicology studies
Contact
Anna Orlowska
Objectives
Main objective is to compare, validate and corroborate the findings of the interaction of the nano-objects synthesised by the network to actual human cell models with the findings observed with the lipid membrane model systems.
Tasks and methodology
Recruited ESR will obtain experience in toxicity, cell- and molecular biological methodology […]

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