Research

ESR6-L: Atomistic and coarse-grained simulations of the interactions of nano-objects and biosurfactants with lipid bilayers

Objectives
This project is focused on the study of the interactions of nano-objects and biosurfactants with lipid bilayers using continuum theory and atomistic and coarse-grained molecular dynamics simulations.

Equilibrium state of stratum corneum (SC) lipid bilayers in contact with keratin corneocytes;
Interaction of nanoparticles and proteins with SC lipid bilayers;
Understanding the role of strongly-asymmetric ceramides in the structure […]

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ESR5-L: Synthesis and characterization of functional biomimetic polymers for intracellular delivery

Chemical synthesis, characterisation of polymers and nano-objects
Objectives
This project is focused on development of functional biomimetic polymers which can traverse across cellular membranes to deliver payloads into the cell interior.

Synthesis and characterization of pH-responsive, membrane-active polymers.
Preparation of therapeutic nanoparticles incorporating chemotherapeutic agents or biological molecules.
Understanding and controlling of the trafficking of polymers into a model cellular […]

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