Research

Coarse-grained Molecular Dynamics

Coarse grained models are becoming increasingly popular to study systems of lipids and surfactants, which means reducing the number of degrees of freedom. Thus, in any coarse grained model there is a trade-off between accuracy in the description of the system and the gain in simulation time and length scales. Coarse grained models can be […]

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Fluoresce-Activated Cell Sorting (FACS)

Flow cytometry is a laser-based biophysical technology employed in cell counting, cell sorting, and biomarker detection. Cells or materials are suspended in a stream of fluid and passed through the electronic detection apparatus. The equipment allows simultaneous multiparametric analysis of physical and chemical characteristics up to thousands of particles per second.

Fluorescence-activated cell sorting (FACS) is […]

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Gel permeation chromatography/ Size exclusion chromatography

Gel permeation chromatography (GPC)/ Size exclusion chromatography (SEC) is a widely used technique for  measuring the molecular weight and molecular weight distribution of natural and synthetic polymers. It is based on  liquid chromatographic techniques that separate individual polymer chains on the basis of their size in solution and not on their chemical properties. The separation […]

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Laser Scanning Confocal Microscopy (LSCM)

Laser Scanning Confocal Microscopy (LSCM) is a fluorescence microscopy technique widely used in the biological and medical field for imaging thin optical sections in living and fixed specimens [1]. Particularly in biophysics and biology it has become an essential tool not only to visualize lipid model membranes, but also to perform spectral imaging and diffusion […]

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Neutron reflection (NR) and Small angle neutron scattering (SANS)

Neutron Reflection (NR) is a highly credible, non-destructive technique used to study the interfaces. It helps to define the interface properties between different material layers, and these layers can be studied with the resolution of the order of angstroms. By measuring the position of interfaces between different materials, the thickness of the layer can be […]

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Nuclear magnetic resonance spectroscopy (NMR spectroscopy)

Nuclear magnetic resonance spectroscopy (NMR spectroscopy) is one of the most widely used techniques by chemists and biologists to identify molecular structures. It relies on the  phenomenon of nuclear magnetic resonance, which means the intramolecular magnetic around an atom in a specific molecular changes the resonance frequency. Thus, different atoms within one molecule could have different resonance […]

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IC – Membrane Biophysics group facilities

The Membrane Biophysics group of Imperial College of London has a range of equipment, much of which is under constant development to ensure we remain at the forefront of membrane biophysics research. They also have two fully equiped preparation labs.
Please see the sections below for a more detailed description of our facilities.

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Atomistic Simulation

Atomistic simulation is the theoretical and computational modelling of what happens at the atomic scale in solids, liquids, molecules and plasmas. It could be perform throughout Molecular Statics and Molecular Dynamics [1, 2].
Molecular dynamics simulations follow the same approach of a real experiment:
The first step is the preparation and the description of a sample of […]

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Spectroscopic ellipsometry (SE)

Ellipsometry is an optical technique for analyzing and characterizing an interface or a layer between two surfaces. The method is based on the measure of the change of polarization as light interacts with the material structure of interest [1]. Ellipsometry is a very used technique, with applications in various fields, as semiconductor physics, microelectronics, biology, […]

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Dual polarization interferometry (DPI)

Dual polarization interferometry [1] is a relatively new technique, which explores the molecular layers adsorbed to the surface of a waveguide by means of an electromagnetic evanescent wave of a laser beam; it measures the refractive index and the thickness of very thin films, and is also used to study the protein adsorption at solid/water […]

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Langmuir trough

The Langmuir trough is a laboratory apparatus used to create and characterize single molecule thick films by controlling the packing density of the molecules. The idea of a Langmuir film was first proposed by Dr. Irving Langmuir in 1917, when he created a single-molecule thin film on water surface.

When a monolayer is fabricated at the […]

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SCMF – Single Chain Mean Field Theory

Basics
The Single Chain Mean Field (SCMF) theory was originally proposed by Ben-Shaul, Szleifer and Gelbart [zotpressInText item=”{QBZPNNQN},{RXXJ3MHB}”] to describe micellization of block copolymers. This method has further been developed to describe the structure of phospholipid membranes at the molecular level[zotpressInText item=”{4KUHSU4T},{QE3GFT2S}”]. SCMF is one of the theoretical tools exploited in the Molecular Simulation group in Tarragona.
 The SCMF theory describes a […]

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