Leeds, UK

Design, synthesis and characterization of biofunctional materials. Formulation of specific drug delivery systems with integrated imaging, targeting and therapeutic functionalities for functional delivery of anticancer drugs and therapeutic proteins and nucleic acids.

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Rongjun Chen group has a proven track record, areas of expertise and superb facilities for design, synthesis and characterization of membrane-active for intracellular delivery and molecular imaging.

Selection of relevant publications



Ahire, Jayshree, Qi Wang, Paul Coxon, Girish Malhotra, Rik Brydson, Rongjun Chen, and Yimin Chao. 2012. "Highly Luminescent and Nontoxic Amine-Capped Nanoparticles from Porous Silicon: Synthesis and Their Use in Biomedical Imaging." ACS Applied Materials & Interfaces, 4 (6): 3285-3292.

Cao, Jiapei, Zhongbin Xu, Baicun Wang, and Rongjun Chen. 2012. "Influence of injection air pressure on the microcapillary formation within extruded plastic films." Journal of Materials Science.

Ho, Vincent, Nigel Slater, and Rongjun Chen. 2011. "pH-responsive endosomolytic pseudo-peptides for drug delivery to multicellular spheroids tumour models." Biomaterials, 32 (11): 2953-2958.

Lynch, Andrew, Rongjun Chen, and Nigel Slater. 2011. "pH-responsive polymers for trehalose loading and desiccation protection of human red blood cells." Biomaterials, 32 (19): 4443-4449.

Metanawin, Tanapak, Tian Tang, Rongjun Chen, David Vernon, and Xiaosong Wang. 2011. "Cytotoxicity and photocytotoxicity of structure-defined water-soluble C 60 / micelle supramolecular nanoparticles." Nanotechnology, 22 (23): 235604.

Zhang, Shengwen, Andrew Nelson, Zachary Coldrick, and Rongjun Chen. 2011. "The Effects of Substituent Grafting on the Interaction of pH-Responsive Polymers with Phospholipid Monolayers." Langmuir, 27 (13): 8530-8539.

Chen, Rongjun, Najeem Folarin, Vincent Ho, David McNally, David Darling, Farzin Farzaneh, and Nigel Slater. 2010. "Affinity recovery of lentivirus by diaminopelargonic acid mediated desthiobiotin labelling." Journal of Chromatography B, 878 (22): 1939-1945.

Ho, Vincent, Karin Müller, Alexander Barcza, Rongjun Chen, and Nigel Slater. 2010. "Generation and manipulation of magnetic multicellular spheroids." Biomaterials, 31 (11): 3095-3102.

Khormaee, Sariah, Rongjun Chen, John Park, and Nigel Slater. 2010. "The Influence of Aromatic Side-Chains on the Aqueous Properties of pH-Sensitive Poly(L-lysine iso-phthalamide) Derivatives." Journal of Biomaterials Science, Polymer Edition, 21 (12): 1573-1588.

Lynch, Andrew, Rongjun Chen, Paul Dominowski, Evgenyi Shalaev, Robert Yancey, and Nigel Slater. 2010. "Biopolymer mediated trehalose uptake for enhanced erythrocyte cryosurvival." Biomaterials, 31 (23): 6096-6103.

Chen, Rongjun, Sariah Khormaee, Mark Eccleston, and Nigel Slater. 2009. "Effect of l -Leucine Graft Content on Aqueous Solution Behavior and Membrane-Lytic Activity of a pH-Responsive Pseudopeptide." Biomacromolecules, 10 (9): 2601-2608.

Chen, Rongjun, Mark Eccleston, Zhilian Yue, and Nigel Slater. 2009. "Synthesis and pH-responsive properties of pseudo-peptides containing hydrophobic amino acid grafts." Journal of Materials Chemistry, 19 (24): 4217.

Chen, Rongjun, Sariah Khormaee, Mark Eccleston, and Nigel Slater. 2009. "The role of hydrophobic amino acid grafts in the enhancement of membrane-disruptive activity of pH-responsive pseudo-peptides." Biomaterials, 30 (10): 1954-1961.

Liechty, William, Rongjun Chen, Farzin Farzaneh, Mahvash Tavassoli, and Nigel Slater. 2009. "Synthetic pH-Responsive Polymers for Protein Transduction." Advanced Materials, 21 (38â??39): 3910-3914.

Chen, Rongjun, Zhilian Yue, Mark Eccleston, and Nigel Slater. 2008. "Aqueous solution behaviour and membrane disruptive activity of pH-responsive PEGylated pseudo-peptides and their intracellular distribution." Biomaterials, 29 (32): 4333-4340.



Chen, Rongjun, Zhilian Yue, Mark Eccleston, Sharon Williams, and Nigel Slater. 2005. "Modulation of cell membrane disruption by pH-responsive pseudo-peptides through grafting with hydrophilic side chains." Journal of Controlled Release, 108 (1): 63-72.