Manchester, UK

Neutron reflection and Spectroscopic ellipsometry (SE) to reveal molecular features underlying surface biocompatibility, controlled local drug and gene delivery and medical implant deployment.

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Experimental studies of biological-material interfacial processes focusing on unravelling the molecular basis of surface biocompatibility. The group is particularly renowned at using neutron reflection, SANS and related techniques for studying the structure and dynamics of interfacial adsorption of DNA and proteins, interfacial assembly of li-pids and the interactions between them.

Selection of relevant publications

Chen., Cuixia, Jing Hu, Shengzhong Zhang, Peng Zhou, Xichen Zhao, Hai Xu, Xiubo Zhao, Mohammed Yaseen, and Jian Lu. 2012. "Molecular mechanisms of antibacterial and antitumor actions of designed surfactant-like peptides." Biomaterials, 33 (2): 592-603.

Han, Shuyi, Wenwen Xu, Cao Meiwen, Wang Jiqian, Daohong Xia, Hai Xu, Xiubo Zhao, and Jian Lu. 2012. "Interfacial adsorption of cationic peptide amphiphiles: a combined study of in situ spectroscopic ellipsometry and liquid AFM." Soft Matter, 8 (3): 645.

Cao, Meiwen, Yuming Wang, Xin Ge, Changhai Cao, Jing Wang, Hai Xu, Daohong Xia, Xiubo Zhao, and Jian Lu. 2011. "Effects of Anions on Nanostructuring of Cationic Amphiphilic Peptides." The Journal of Physical Chemistry B, 115 (41): 11862-11871.

Han, Shuyi, Sasa Cao, Yuming Wang, Jiqian Wang, Daohong Xia, Hai Xu, Xiubo Zhao, and Jian Lu. 2011. "Self-Assembly of Short Peptide Amphiphiles: The Cooperative Effect of Hydrophobic Interaction and Hydrogen Bonding." Chemistry - A European Journal, 17 (46): 13095-13102.

Hu, Jing, Cuixia Chen., Shengzhong Zhang, Xichen Zhao, Hai Xu, Xiubo Zhao, and Jian Lu. 2011. "Designed Antimicrobial and Antitumor Peptides with High Selectivity." Biomacromolecules, 12 (11): 3839-3843.

Jia, Donghui, Kai Tao, Jiqian Wang, Chengdong Wang, Xiubo Zhao, Mohammed Yaseen, Hai Xu, Guohe Que, John Webster, and Jian Lu. 2011. "Dynamic Adsorption and Structure of Interfacial Bilayers Adsorbed from Lipopeptide Surfactants at the Hydrophilic Silicon/Water Interface: Effect of the Headgroup Length." Langmuir, 27 (14): 8798-8809.