Cambridge, UK

Targeted delivery strategies for DNA and viral therapeutics using a range of novel strategies, the improvement of the long term stability of biopharmaceuticals by lyophilisation and new affinity methods for their purification.

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Nigel Slater has developed biosynthetic materials that facilitate the delivery of payloads into cells. This technology mimics the efficient viral transfection within a synthetic polymer framework. In in-vitro cul-tured cells, amphiphilic polymers display endosmolytic behaviour and traffic rapidly to the nucleus. PEGylated doxorubicin-conjugated constructs are toxic in in-vitro tumour cell models and evade efflux mechanisms in multidrug resistant cells.

Selection of relevant publications



Pogodin, Sergey, Nigel Slater, Vladimir Baulin, and Vladimir Baulin. 2012. "Biomolecule Surface Patterning May Enhance Membrane Association." ACS Nano, 6 (2): 1308-1313.

Ho, Vincent, Nigel Slater, and Rongjun Chen. 2011. "pH-responsive endosomolytic pseudo-peptides for drug delivery to multicellular spheroids tumour models." Biomaterials, 32 (11): 2953-2958.

Lynch, Andrew and Nigel Slater. 2011. "Influence of intracellular trehalose concentration and pre-freeze cell volume on the cryosurvival of rapidly frozen human erythrocytes." Cryobiology, 63 (1): 26-31.

Lynch, Andrew, Rongjun Chen, and Nigel Slater. 2011. "pH-responsive polymers for trehalose loading and desiccation protection of human red blood cells." Biomaterials, 32 (19): 4443-4449.

Lynch, Andrew, Bo Dury, Christian Guyader, and Nigel Slater. 2011. "Sugars Comparable to Glutathione as Hemoglobin Oxidation Protectants During Vacuum Drying." Biopreservation and Biobanking, 9 (4): 411-413.

Pogodin, Sergey, Nigel Slater, Vladimir Baulin, and Vladimir Baulin. 2011. "Surface Patterning of Carbon Nanotubes Can Enhance Their Penetration through a Phospholipid Bilayer." ACS Nano, 5 (2): 1141-1146.

Chen, Rongjun, Najeem Folarin, Vincent Ho, David McNally, David Darling, Farzin Farzaneh, and Nigel Slater. 2010. "Affinity recovery of lentivirus by diaminopelargonic acid mediated desthiobiotin labelling." Journal of Chromatography B, 878 (22): 1939-1945.

Ho, Vincent, Karin Müller, Alexander Barcza, Rongjun Chen, and Nigel Slater. 2010. "Generation and manipulation of magnetic multicellular spheroids." Biomaterials, 31 (11): 3095-3102.

Khormaee, Sariah, Rongjun Chen, John Park, and Nigel Slater. 2010. "The Influence of Aromatic Side-Chains on the Aqueous Properties of pH-Sensitive Poly(L-lysine iso-phthalamide) Derivatives." Journal of Biomaterials Science, Polymer Edition, 21 (12): 1573-1588.

Lynch, Andrew, Rongjun Chen, Paul Dominowski, Evgenyi Shalaev, Robert Yancey, and Nigel Slater. 2010. "Biopolymer mediated trehalose uptake for enhanced erythrocyte cryosurvival." Biomaterials, 31 (23): 6096-6103.

Chen, Rongjun, Sariah Khormaee, Mark Eccleston, and Nigel Slater. 2009. "Effect of l -Leucine Graft Content on Aqueous Solution Behavior and Membrane-Lytic Activity of a pH-Responsive Pseudopeptide." Biomacromolecules, 10 (9): 2601-2608.

Chen, Rongjun, Mark Eccleston, Zhilian Yue, and Nigel Slater. 2009. "Synthesis and pH-responsive properties of pseudo-peptides containing hydrophobic amino acid grafts." Journal of Materials Chemistry, 19 (24): 4217.

Chen, Rongjun, Sariah Khormaee, Mark Eccleston, and Nigel Slater. 2009. "The role of hydrophobic amino acid grafts in the enhancement of membrane-disruptive activity of pH-responsive pseudo-peptides." Biomaterials, 30 (10): 1954-1961.

Liechty, William, Rongjun Chen, Farzin Farzaneh, Mahvash Tavassoli, and Nigel Slater. 2009. "Synthetic pH-Responsive Polymers for Protein Transduction." Advanced Materials, 21 (38â??39): 3910-3914.

Chen, Rongjun, Zhilian Yue, Mark Eccleston, and Nigel Slater. 2008. "Aqueous solution behaviour and membrane disruptive activity of pH-responsive PEGylated pseudo-peptides and their intracellular distribution." Biomaterials, 29 (32): 4333-4340.



Chen, Rongjun, Zhilian Yue, Mark Eccleston, Sharon Williams, and Nigel Slater. 2005. "Modulation of cell membrane disruption by pH-responsive pseudo-peptides through grafting with hydrophilic side chains." Journal of Controlled Release, 108 (1): 63-72.

Yue, Z, M Eccleston, and N Slater. 2005. "Modulation of the pH-responsive properties of poly(-lysine -phthalamide) grafted with a poly(ethylene glycol) analogue." Biomaterials, 26 (32): 6357-6366.