Association of polymers and small solute molecules with phospholipid membranes

  • Interests: Mathematics and Physics (theory)
  • Education: College of Mathematics and Physics in Nanjing University of Information Science & Technology, Nanjing, China (2011 with honors)
  • Master: Universitat Rovira i Virgili 2012
  • Supervisor: Vladimir Baulin

Yachong Guo

Short Bio

My education..

2012-2016 PhD student. Universitat Rovira i Virgili, Tarragona, Spain
2011 – 2012 MSc degree. Universitat Rovira i Virgili, Tarragona, Spain
2010 – 2012 BSc Physics. China

PhD Project

  • Association of polymers and small solute molecules with phospholipid membranes

    Theoretical physics, theory in soft matter, computer simulations

    In many cases the properties of cell membranes are modified through biopolymers and small solute molecules such as anesthetics or neurotransmitters. They can associate to membranes and significantly alter their structure, either thermodynamic state or induce reorganization in form of pores. The project aims to describe the fundamental controls of these processes that trigger such membrane modification or structural reorganization using the Single Chain Mean Field (SCMF) theory.
    Tasks and methodology

    Implementation of a hybrid Single Chain Mean Field theory with Monte Carlo simulations
    Construction of the …

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  • Unexpected Cholesterol-Induced Destabilization of Lipid Membranes near Transmembrane Carbon Nanotubes

    Phys. Rev. Lett. 124(3), 038001 (2020)
    Yachong Guo, Marco Werner, Jean Baptiste Fleury and Vladimir A. Baulin

    Cholesterol is a crucial component of mammalian cell membranes that takes part in many vital processes. It is generally accepted that cholesterol stabilizes the membrane and induces transitions into ordered states. In contrast to expectations, …

  • Tension-Induced Translocation of Ultra-Short Carbon Nanotube through a Phospholipid Bilayer

    ACS Nano, November (2018)
    Yachong Guo, Marco Werner, Ralf Seemann, Vladimir A Baulin, and Jean-Baptiste Fleury
    Increasing awareness of bioeffects and toxicity of nanomaterials interacting with cells puts in focus the mechanisms by which nanomaterials can cross lipid membranes. Apart from well-discussed energy-dependent endocytosis for large objects and passive diffusion through membranes …

  • Bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite

    Acta Biomaterialia, 59, 148-157 (2017).
    Elena P. Ivanova, Song Ha Nguyen, Yachong Guo, Vladimir A. Baulin, Hayden K. Webb, Vi Khanh Truong, Jason V. Wandiyanto, Christopher J. Garvey, Peter
    J. Mahon, David E. Mainwaring, Russell J. Crawford
    The wings of insects such as cicadas and dragonflies have been found to exhibit nanostructure arrays that …

  • Apatite nanoparticles strongly improve red blood cell cryopreservation by mediating trehalose delivery via enhanced membrane permeation

    Biomaterials, 140, 138-149 (2017).
    Martin Stefanic, Kevin Ward, Harvey Tawfik, Ralf Seemann, Vladimir Baulin, Yachong Guo, Jean-Baptiste Fleury, Christophe Drouet
    Cryopreservation of red blood cells (RBC) is an important method for maintaining an inventory of rare RBC units and managing special transfusion circumstances. Currently, in a clinical setting, glycerol is used as …

  • GPU implementation of the Rosenbluth generation method for static Monte Carlo simulations

    Computer Physics Communications, 216, 95–101(2017).
    Yachong Guo, Vladimir A. Baulin
    We present parallel version of Rosenbluth Self-Avoiding Walk generation method implemented on Graphics Processing Units (GPUs) using CUDA libraries. The method scales almost linearly with the number of CUDA cores and the method efficiency has only hardware limitations. The method is introduced …

  • Direct proof of spontaneous translocation of lipid-covered hydrophobic nanoparticles through a phospholipid bilayer

    Science Advances 2 (11), e1600261 (2016)
    Yachong Guo, Emmanuel Terazzi, Ralf Seemann, Jean Baptiste Fleury and Vladimir A. Baulin

    Hydrophobic nanoparticles introduced into living systems may lead to increased toxicity, can activate immune cells, or can be used as nanocarriers for drug or gene delivery. It is generally accepted that small hydrophobic nanoparticles are blocked by lipid …

  • Peroxidised phospholipid bilayers: insight from Coarse-Grained Molecular Dynamics simulations

    Soft Matter, 12, 263-271 (2016)
    Yachong Guo, Vladimir Baulin and Fabrice Thalmann

    An original coarse-grained model for peroxidised phospholipids is presented, based on the MARTINI lipid force field. This model results from a combination of thermodynamic modelling and structural information on the area per lipid, which have been made available recently. The resulting coarse-grained …

  • Graphene Induces Formation of Pores That Kill Spherical and Rod-Shaped Bacteria

    ACS Nano, DOI: 10.1021/acsnano.5b03368 (2015)
    Vy T. H. Pham, Vi Khanh Truong, Matthew D. J. Quinn, Shannon M. Notley, Yachong Guo, Vladimir A. Baulin, Mohammad Al Kobaisi, Russell J. Crawford, and Elena P. Ivanova

    Pristine graphene, its derivatives, and composites have been widely reported to possess antibacterial properties. Most of the studies simulating …

  • General model of phospholipid bilayers in fluid phase within the single chain mean field theory

    J. Chem. Phys. 140, 174903 (2014)
    Yachong Guo, Sergey Pogodin and Vladimir A. Baulin

    Coarse-grained model for saturated phospholipids: 1,2-didecanoyl-sn-glycero-3-phosphocholine (DCPC), 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and unsaturated phospholipids: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2- dioleoyl-sn-glycero-3-phosphocholine (DOPC) is introduced within the single chain mean field theory. A single set of parameters adjusted for DMPC …

  • Nanotopography as a trigger for the microscale, autogenous and passive lysis of erythrocytes

    J. Mater. Chem. B, 2 (19), 2785-2948 (2014)
    Vy T. H. Pham, Vi Khanh Truong, David E. Mainwaring, Yachong Guo, Vladimir Baulin, Mohammad Al Kobaisi,   Gediminas Gervinskas, Saulius Juodkazis, Wendy R. Zeng, Pauline Doran, Russell J Crawford and Elena P. Ivanova

    Microscale devices are increasingly being developed for diagnostic analysis although conventional lysis …

  • Lipid oxidation induces structural changes in biomimetic membranes

    Soft Matter, 10, 4241-4247 (2014)
    G. Weber, T. Charitat, M. S. Baptista, A. F. Uchoa, C. Pavani, H. C. Junqueira, Y. Guo, V. A. Baulin, R. Itri, C. M. Marques, A. P. Schroder

    Oxidation can intimately influence and structurally compromise the levels of biological self-assembly embodied by intracellular and plasma membranes. Lipid peroxidation, …