Association of polymers and small solute molecules with phospholipid membranes
- Interests: Mathematics and Physics (theory)
- Education: College of Mathematics and Physics in Nanjing University of Information Science & Technology, Nanjing, China (2011 with honors)
- Master: Universitat Rovira i Virgili 2012
- Supervisor: Vladimir Baulin
Short Bio
My education..
2012-2016 | PhD student. Universitat Rovira i Virgili, Tarragona, Spain |
2011 – 2012 | MSc degree. Universitat Rovira i Virgili, Tarragona, Spain |
2010 – 2012 | BSc Physics. China |
PhD Project
- Association of polymers and small solute molecules with phospholipid membranes
Theoretical physics, theory in soft matter, computer simulations Objectives In many cases the properties of cell membranes are modified through biopolymers and small solute molecules such as anesthetics or neurotransmitters. They can associate to membranes and significantly alter their structure, either thermodynamic state or induce reorganization in form of pores. The project aims to describe the fundamental controls of these processes that trigger such membrane modification or structural reorganization using the Single Chain Mean Field (SCMF) theory. Tasks and methodology Implementation of a hybrid Single Chain Mean Field theory with Monte Carlo simulations Construction of the ...
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Publications
- Unexpected Cholesterol-Induced Destabilization of Lipid Membranes near Transmembrane Carbon Nanotubes
Phys. Rev. Lett. 124(3), 038001 (2020) Yachong Guo, Marco Werner, Jean Baptiste Fleury and Vladimir A. Baulin Cholesterol is a crucial component of mammalian cell membranes that takes part in many vital processes. It is generally accepted that cholesterol stabilizes the membrane and induces transitions into ordered states. In contrast to expectations, ...
- Tension-Induced Translocation of Ultra-Short Carbon Nanotube through a Phospholipid Bilayer
ACS Nano, November (2018) Yachong Guo, Marco Werner, Ralf Seemann, Vladimir A Baulin, and Jean-Baptiste Fleury Increasing awareness of bioeffects and toxicity of nanomaterials interacting with cells puts in focus the mechanisms by which nanomaterials can cross lipid membranes. Apart from well-discussed energy-dependent endocytosis for large objects and passive diffusion through membranes ...
- Bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite
Acta Biomaterialia, 59, 148-157 (2017). Elena P. Ivanova, Song Ha Nguyen, Yachong Guo, Vladimir A. Baulin, Hayden K. Webb, Vi Khanh Truong, Jason V. Wandiyanto, Christopher J. Garvey, Peter J. Mahon, David E. Mainwaring, Russell J. Crawford The wings of insects such as cicadas and dragonflies have been found to exhibit nanostructure arrays that ...
- Apatite nanoparticles strongly improve red blood cell cryopreservation by mediating trehalose delivery via enhanced membrane permeation
Biomaterials, 140, 138-149 (2017). Martin Stefanic, Kevin Ward, Harvey Tawfik, Ralf Seemann, Vladimir Baulin, Yachong Guo, Jean-Baptiste Fleury, Christophe Drouet Cryopreservation of red blood cells (RBC) is an important method for maintaining an inventory of rare RBC units and managing special transfusion circumstances. Currently, in a clinical setting, glycerol is used as ...
- GPU implementation of the Rosenbluth generation method for static Monte Carlo simulations
Computer Physics Communications, 216, 95–101(2017). Yachong Guo, Vladimir A. Baulin We present parallel version of Rosenbluth Self-Avoiding Walk generation method implemented on Graphics Processing Units (GPUs) using CUDA libraries. The method scales almost linearly with the number of CUDA cores and the method efficiency has only hardware limitations. The method is introduced ...
- Direct proof of spontaneous translocation of lipid-covered hydrophobic nanoparticles through a phospholipid bilayer
Science Advances 2 (11), e1600261 (2016) Yachong Guo, Emmanuel Terazzi, Ralf Seemann, Jean Baptiste Fleury and Vladimir A. Baulin Hydrophobic nanoparticles introduced into living systems may lead to increased toxicity, can activate immune cells, or can be used as nanocarriers for drug or gene delivery. It is generally accepted that small hydrophobic nanoparticles are blocked by lipid ...
- Peroxidised phospholipid bilayers: insight from Coarse-Grained Molecular Dynamics simulations
Soft Matter, 12, 263-271 (2016) Yachong Guo, Vladimir Baulin and Fabrice Thalmann An original coarse-grained model for peroxidised phospholipids is presented, based on the MARTINI lipid force field. This model results from a combination of thermodynamic modelling and structural information on the area per lipid, which have been made available recently. The resulting coarse-grained ...
- Graphene Induces Formation of Pores That Kill Spherical and Rod-Shaped Bacteria
ACS Nano, DOI: 10.1021/acsnano.5b03368 (2015) Vy T. H. Pham, Vi Khanh Truong, Matthew D. J. Quinn, Shannon M. Notley, Yachong Guo, Vladimir A. Baulin, Mohammad Al Kobaisi, Russell J. Crawford, and Elena P. Ivanova Pristine graphene, its derivatives, and composites have been widely reported to possess antibacterial properties. Most of the studies simulating ...
- General model of phospholipid bilayers in fluid phase within the single chain mean field theory
J. Chem. Phys. 140, 174903 (2014) Yachong Guo, Sergey Pogodin and Vladimir A. Baulin Coarse-grained model for saturated phospholipids: 1,2-didecanoyl-sn-glycero-3-phosphocholine (DCPC), 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and unsaturated phospholipids: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2- dioleoyl-sn-glycero-3-phosphocholine (DOPC) is introduced within the single chain mean field theory. A single set of parameters adjusted for DMPC ...
- Nanotopography as a trigger for the microscale, autogenous and passive lysis of erythrocytes
J. Mater. Chem. B, 2 (19), 2785-2948 (2014) Vy T. H. Pham, Vi Khanh Truong, David E. Mainwaring, Yachong Guo, Vladimir Baulin, Mohammad Al Kobaisi, Gediminas Gervinskas, Saulius Juodkazis, Wendy R. Zeng, Pauline Doran, Russell J Crawford and Elena P. Ivanova Microscale devices are increasingly being developed for diagnostic analysis although conventional lysis ...
- Lipid oxidation induces structural changes in biomimetic membranes
Soft Matter, 10, 4241-4247 (2014) G. Weber, T. Charitat, M. S. Baptista, A. F. Uchoa, C. Pavani, H. C. Junqueira, Y. Guo, V. A. Baulin, R. Itri, C. M. Marques, A. P. Schroder Oxidation can intimately influence and structurally compromise the levels of biological self-assembly embodied by intracellular and plasma membranes. Lipid peroxidation, ...