Research

Post-doc position: Biophysical properties of chromatin

The project

Mutations in chromatin regulators can lead to multiple pathological conditions which are commonly referred as chromatinopathies (CPs). The project –funded by Telethon Foundation- is centered on determining the mechanisms and functional implications of mutations in chromatin regulators observed in CPs by adopting biophysical approaches. The herein program aims to define the role of chromatin-associated condensates in determining the nuclear mechanical properties and their impacts on nuclear architecture in CPs. The successful candidate will combine biochemical and single-molecule dynamics technologies with quantitative data analysis and biophysical modeling. His/Her project will benefit from working within an interdisciplinary framework, favoring cross-contamination of ideas and research discussions

The candidate

We are seeking highly motivated and enthusiastic candidates, willing to challenge an innovative project by adopting a pro-active attitude and an analytical approach. The candidate is requested to have experience in biophysics and molecular biology, aiming to investigate the organization and the dynamic assembly of condensates. The successful candidate will be involved in an interdisciplinary project with research being conducted at the crossroad between computational science, biophysics and molecular biology. Given the international framework, the candidate should also have good communication skills and a team-oriented working attitude.

Qualifications:

  • A high level of motivation and interest.
  • PhD in Physics, Biophysics, Bioengineering, Computer science, Biology or in related fields
  • Prior research experience in macromolecule biophysics, soft matter physics, phase transition and/or molecular biology, (including a track record of peer-reviewed publications) will be recommended
  • Proficiency in scripting environments for statistics and data analysis, and/or able to quickly acquire Bioinformatics computational skills
  • Excellent communication skills and good team spirit with the ability to solve problems independently
  • Knowledge in chromatin biology or molecular biology will be considered a relevant plus.

The environment

The lab of Chromatin Biology and Epigenetics is interested in determining the contribution of epigenetic changes to stem cell function, both in physiological and pathological settings. Within the international and vibrant context of the Center of Integrative Biology (CIBIO) in Trento, Italy. Postdoctoral researchers joining the lab gain access to the Institute’s advanced research training and career development opportunities. CIBIO offers the possibility to work in a young, highly dynamic and stimulating research environment thanks to a streamlined organization, which support researchers to readily adapt to new scientific challenges through cutting-edge research infrastructures. At CIBIO, research goals are pursued in the frame of an integrative view of basic biological processes and of their derangement in disease, whereby basic science co-exists with biomedical oriented translational approaches.

Qualified and interested candidates should submit their application including CV, a motivation letter describing how her/his background would best fit this position, and the contact information of at least two referees. Please send all documents to Prof. Alessio Zippo ([email protected]). Applications will be considered until the position is filled.