Research

Kinetic evolution of DOPC lipid bilayers exposed to α-cyclodextrins

Soft Matter, , (2018)
Monika Kluzek, Marc Schmutz, Carlos M. Marques and Fabrice Thalmann
Cyclodextrins are cyclic oligosaccharides capable of forming inclusion complexes with a variety of molecules, and as such have been recognized as a pharmaceutical and biotechnological asset. Cyclodextrins are known to interact with the components of cell membranes, and this correlates with a significant […]

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DPPC Bilayers in Solutions of High Sucrose Content

Biophysical J, 114(9), 2165–2173 (2018)
Mattia I. Morandi, Mathieu Sommer, Monika Kluzek, Fabrice Thalmann, André P. Schroder, Carlos M. Marques
The properties of lipid bilayers in sucrose solutions have been intensely scrutinized over recent decades because of the importance of sugars in the field of biopreservation. However, a consensus has not yet been formed on the mechanisms […]

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Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Soft Matter, 13, 7571-7577 (2017)
Monika Kluzek, Arwen I. I. Tyler, Shiqi Wang, Rongjun Chen, Carlos M. Marques, Fabrice Thalmann, John M. Seddon, Marc Schmutz
Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers. They provide an appealing road towards the practical use of lipid cubic phases for pharmaceutical and cosmetic […]

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ESR8-S: Kinetics of nanoscale structural changes occurring in small unilamellar vesicles

Experimental investigation of unilamellar vesicles using microscopy techniques
Contact
Monika Kluzek
Description
Experimental project on small unilamellar lipid vesicles (SUV) interacting with nanoparticles, with special emphasis on the use of transmission electron microscopy (cryo-TEM). This project will consist in elaborating, characterizing and studying in detail decorated liposomes, using state of the art techniques such as EM tomography and time […]

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