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Theoretical methods and computer simulations of polymers at surfaces and interfaces, nanoparticles, polymer networks.
Jens-Uwe Sommer expertise is analytical theory and scaling models of polymers. Simulation methods, in particular lattice Monte Carlo methods and Molecular Dynamics.
Various aspects of investigative pathology, which aims at unraveling the mechanisms by which diseases arise and progress.
All facilities are available in the REPAIR-lab of the institute for state-of-the-art cell and molecular biology, including tissue culture, biochemical analysis (ELISA, cell-EIA, Western blot), modern microscopic techniques including immunocytochemistry (confo-cal laser scanning microscopy as well as quantitative morphometric analysis of human cells in both static and dynamic culture), cell transfection by plasmid vectors, nucleic acid analysis for gene expression
Theory and computer simulations and numerical self-consistent field theory. Statistical physics of soft matter with special focus on polymer physics, interfacial and wetting phenomena, and biologically motivated problems.
Marcus Muller research interests include polymer solutions and melts, collective phenomena in membranes and self-assembly, kinetics of phase transitions, wetting and phase diagrams in confined geometry, computer simulation methodology
Targeted delivery strategies for DNA and viral therapeutics using a range of novel strategies, the improvement of the long term stability of biopharmaceuticals by lyophilisation and new affinity methods for their purification.
The Bioscience Engineering Group (BSEG), Cambridge University, UK collaborates widely with academia and industry in the UK, Europe and US to develop novel strategies for the manufacture, formulation and delivery of biopharmaceuticals. The emphasis is on highly potent biological medicines and in recent years the group has worked on the primary and secondary processing of mammalian cell culture products, the processing of serum proteins, viral vaccines and DNA gene therapy vectors.
Nigel Slater has developed biosynthetic materials that facilitate the delivery of payloads into cells. This technology mimics the efficient viral transfection within a synthetic polymer framework. In in-vitro cul-tured cells, amphiphilic polymers display endosmolytic behaviour and traffic rapidly to the nucleus. PEGylated doxorubicin-conjugated constructs are toxic in in-vitro tumour cell models and evade efflux mechanisms in multidrug resistant cells.
Neutron reflection and Spectroscopic ellipsometry (SE) to reveal molecular features underlying surface biocompatibility, controlled local drug and gene delivery and medical implant deployment.
Experimental studies of biological-material interfacial processes focusing on unravelling the molecular basis of surface biocompatibility. The group is particularly renowned at using neutron reflection, SANS and related techniques for studying the structure and dynamics of interfacial adsorption of DNA and proteins, interfacial assembly of li-pids and the interactions between them.
Design, synthesis and characterization of biofunctional materials. Formulation of specific drug delivery systems with integrated imaging, targeting and therapeutic functionalities for functional delivery of anticancer drugs and therapeutic proteins and nucleic acids.
Rongjun Chen group has a proven track record, areas of expertise and superb facilities for design, synthesis and characterization of membrane-active for intracellular delivery and molecular imaging.
Developing novel, functional nanomaterials and structures, investigating their unique properties and exploring their applications. Smart nanoparticle-aptamer sensors, Nanoparticle-bioconjugate devices, Single-molecule studies.
Dejian Zhou group has a proven track record, areas of expertise and superb facilities for design, synthesis and characterization of membrane-active for intracellular delivery and molecular imaging.
Self-assembled phospholipid bilayers; Vesicles, liposomes and supported membranes;
Structure, characterization and control of Soft Matter by microforce techniques.
Carlos Marques is a head of M3 team is entirely devoted to the experimental study and theoretical interpretation of phospholipid based model membranes experiments: preparation and manipulation of giant unilamellar vesicles that are observed by means of optical microscopy.
Theory and simulations of soft matter including hydrodynamics and phase transitions in lipid systems.
Fabrice Thalmann main expertise is theory and computer simulations of soft matter systems.
Theory of Soft matter, polymer physics and biophysics. One of the main research lines is the development of the Single Chain Mean Field (SCMF) theory, a simulation tool able to predict the properties of nanostructures.
Vladimir Baulin expertise is computer simulations and theory of soft matter systems. Theoretical methods and techniques include Single Chain Mean Field theory, a tool for describing equilibrium properties.
Theoretical and experimental thermodynamics and spectroscopy of biological systems. Transitions in biomembranes, artificial lipid membranes and proteins. This includes studies on melting transitions, shape changes of lipid vesicles, protein unfolding, relaxation, and permeability.
Application of molecular spectroscopy and photophysics methods to biological problems, including cell imaging/environmental mapping, cell capture, sensing and membrane mimetics.
Molecular spectroscopy and photophysics group, School of Chemical Sciences, Dublin City University, Dublin, Ireland
Tia Keyes expertise lies in the field of photochemistry and spectroscopy; Supramolecular interfacial chemistry; Luminescent polymers and supermolecules for sensing; Nanoscale Interfacial platforms for surface enhanced bio-Raman spectroscopy; Luminescent probes for heterogeneous microenvironments and biomaterials
Washington DC, USA
Complex fluids, including biological fluids (membranes, polymers, etc), from the point of view of a condensed matter physicist interested in statistical mechanics.
Peter Olmsted is expert in computer simulation of lipid bilayers, development of new computational methods for analyzing permeation and penetration through lipid membranes
Fargo ND, USA
Thermodynamics of lipid membranes and interactions with biopolymers, electrostatics in soft matter systems.
Sylvio May expertise lies in thermodynamics of lipid membranes and interactions with biopolymers; Electrostatics, Poisson-Boltzmann theory, ionic interactions in soft matter systems
Modeling the kinetics of liposomal drug delivery
Expertise in Microbiology and Biotechnology/Nanobiotechnology. Design, fabrication and operation of planar micro-devices, immobilization of bio-molecules and micro-organisms in micro/nano/environments, bacterial interactions with macro/micro/nano-structured surfaces.
Elena Ivanova Nanobiotechnology group at Swinburne is internationally recognised as one of the leading groups at investigating bacterial attachment on surfaces of micro- and nano restricted topographies.
Auckland, New Zealand
Surface structures of biological systems using surface sensitive methods, particularly neutron and X-ray scattering.
Duncan McGillivray is expert in neutron scattering. The School of Chemical Sciences at the University of Auckland is equipped with X-ray and complementary characterisation methods (including ATR-IR, Electrical impedance spectroscopy, ellipsometry) for model biological membranes, and has routine access to the Australian OPAL reactor neutron source and the Australian Synchrotron, which are world class neutron and X-ray sources.
Design and synthesis of new functional materials based on bio-nano-materials, engineering. Smart nano-materials and assembly of drugs and biological macromolecules and intelligent nano carrier material in the biological and medical applications.
Youqing Shen expertise in drug delivery, in-vivo testing and bio-mecicine